As a person gains weight muscles become progressively more inefficient, resulting in easier fatigue and varying degrees of insulin resistance. Instead of a smooth production of energy, muscle cells in overweight people make increasing amounts of free radicals. These free radicals damage the mitochondria Organelle found in cells that produce ATP or chemical energy. Also involved with cell signaling, cellular differentiation, cell death, cell growth, along with heme and steroid synthesis. of muscle cells, triggering the natural process of autophagy, which either tries to clean up the damage or recycle the cell if it is too damaged (meaning cell death). Unfortunately, for those in poor metabolic condition the tendency of autophagy is to trigger cell death in muscles, leading to progressively worse insulin resistance. It is a snowballing effect in the wrong direction, a problem faced by tens of millions of overweight Americans.